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In placebo controlled medical trials of adult people quetiapine was connected to an increased incidence of extrapyramidal signs (EPS) when compared to placebo in clients addressed for main depressive episodes in bipolar dysfunction.

For preventing recurrence in bipolar dysfunction For preventing recurrence of manic, mixed or depressive episodes in bipolar dysfunction, sufferers that have responded to quetiapine for acute procedure of bipolar ailment should carry on therapy at the exact same dose. The dose could be adjusted dependant upon clinical response and tolerability of the person patient, within the selection of 300 to 800 mg/day administered two times each day. It can be crucial that the bottom powerful dose is employed for routine maintenance therapy.

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